Summary information and primary citation
- PDB-id
-
7lv8;
SNAP-derived features in text and
JSON formats
- Class
- structural protein-DNA
- Method
- cryo-EM (3.4 Å)
- Summary
- Structure of the marseillevirus nucleosome
- Reference
-
Valencia-Sanchez MI, Abini-Agbomson S, Wang M, Lee R,
Vasilyev N, Zhang J, De Ioannes P, La Scola B, Talbert P,
Henikoff S, Nudler E, Erives A, Armache KJ (2021):
"The
structure of a virus-encoded nucleosome."
Nat.Struct.Mol.Biol., 28,
413-417. doi: 10.1038/s41594-021-00585-7.
- Abstract
- Certain large DNA viruses, including those in the
Marseilleviridae family, encode histones. Here we show that
fused histone pairs Hβ-Hα and Hδ-Hγ from Marseillevirus are
structurally analogous to the eukaryotic histone pairs
H2B-H2A and H4-H3. These viral histones form 'forced'
heterodimers, and a heterotetramer of four such
heterodimers assembles DNA to form structures virtually
identical to canonical eukaryotic nucleosomes.
