DSSR-PyMOL cartoon-block schematics: PDB entry 6m6k

PDB-id

6m6k; DSSR-derived features in text and JSON formats

Class

DNA

Method

NMR

Summary

NMR solution structure of a DNA minidumbbell containing an abasic bulge between two cctg repeats

Reference

Wan L, Lam SL, Lee HK, Guo P (2020): "Rational design of a reversible Mg2+/EDTA-controlled molecular switch based on a DNA minidumbbell." Chem.Commun.(Camb.), 56, 10127-10130. doi: 10.1039/d0cc03774e.

Abstract

Here we report that incorporation of an abasic site to DNA minidumbbells formed by natural sequences can lead to significant enhancements in their thermodynamic stability. Based on these stable minidumbbells, the first metal ion-controlled molecular switch which can regulate instant and reversible DNA duplex formation and dissociation has been constructed.