DSSR-PyMOL cartoon-block schematics: PDB entry 6jwe

PDB-id

6jwe; DSSR-derived features in text and JSON formats

Class

DNA

Method

NMR

Summary

Structure of ret g-quadruplex in complex with colchicine

Reference

Wang F, Wang C, Liu Y, Lan W, Han H, Wang R, Huang S, Cao C (2020): "Colchicine selective interaction with oncogene RET G-quadruplex revealed by NMR." Chem.Commun.(Camb.), 56, 2099-2102. doi: 10.1039/d0cc00221f.

Abstract

G-quadruplexes (G4s) are frequently formed in the promoter regions of oncogenes, considered as promising drug targets for anticancer therapy. Due to high structure similarity of G4s, discovering ligands selectively interacting with only one G4 is extremely difficult. Here, mainly by NMR, we report that colchicine selectively binds to oncogene RET G4-DNA.