Summary information and primary citation
- PDB-id
- 5yej; DSSR-derived features in text and JSON formats
- Class
- DNA binding protein-DNA
- Method
- X-ray (2.698 Å)
- Summary
- Crystal structure of bioq with its naturel double-stranded DNA operator
- Reference
- Yan L, Tang Q, Guan Z, Pei K, Zou T, He J (2018): "Structural insights into operator recognition by BioQ in the Mycobacterium smegmatis biotin synthesis pathway." Biochim Biophys Acta Gen Subj, 1862, 1843-1851. doi: 10.1016/j.bbagen.2018.05.015.
- Abstract
- Background: Biotin is an essential cofactor in living organisms. The TetR family transcriptional regulator (TFTR) BioQ is the main regulator of biotin synthesis in Mycobacterium smegmatis. BioQ represses the expression of its target genes by binding to a conserved palindromic DNA sequence (the BioQ operator). However, the mechanism by which BioQ recognizes this DNA element has not yet been fully elucidated.
