Summary information and primary citation
- PDB-id
- 5lfw; DSSR-derived features in text and JSON formats
- Class
- DNA
- Method
- X-ray (1.28 Å)
- Summary
- Lambda-[ru(phen)2(dppz)]2+ bound to a short substituted DNA sequence
- Reference
- Hall JP, Gurung SP, Henle J, Poidl P, Andersson J, Lincoln P, Winter G, Sorensen T, Cardin DJ, Brazier JA, Cardin CJ (2017): "Guanine Can Direct Binding Specificity of Ru-dipyridophenazine (dppz) Complexes to DNA through Steric Effects." Chemistry, 23, 4981-4985. doi: 10.1002/chem.201605508.
- Abstract
- X-ray crystal structures of three Λ-[Ru(L)2 dppz](2+) complexes (dppz=dipyridophenazine; L=1,10-phenanthroline (phen), 2,2'-bipyridine (bpy)) bound to d((5BrC)GGC/GCCG) showed the compounds intercalated at a 5'-CG-3' step. The compounds bind through canted intercalation, with the binding angle determined by the guanine NH2 group, in contrast to symmetrical intercalation previously observed at 5'-TA-3' sites. This result suggests that canted intercalation is preferred at 5'-CG-3' sites even though the site itself is symmetrical, and we hypothesise that symmetrical intercalation in a 5'-CG-3' step could give rise to a longer luminescence lifetime than canted intercalation.
