Summary information and primary citation

PDB-id
4u9m; DSSR-derived features in text and JSON formats
Class
DNA
Method
X-ray (3.13 Å)
Summary
Structure of the DNA duplex d(attaat)2 with hoogsteen hydrogen bonds
Reference
Acosta-Reyes FJ, Alechaga E, Subirana JA, Campos JL (2015): "Structure of the DNA Duplex d(ATTAAT)2 with Hoogsteen Hydrogen Bonds." Plos One, 10, e0120241. doi: 10.1371/journal.pone.0120241.
Abstract
The traditional Watson-Crick base pairs in DNA may occasionally adopt a Hoogsteen conformation, with a different organization of hydrogen bonds. Previous crystal structures have shown that the Hoogsteen conformation is favored in alternating AT sequences of DNA. Here we present new data for a different sequence, d(ATTAAT)2, which is also found in the Hoogsteen conformation. Thus we demonstrate that other all-AT sequences of DNA with a different sequence may be found in the Hoogsteen conformation. We conclude that any all-AT sequence might acquire this conformation under appropriate conditions. We also compare the detailed features of DNA in either the Hoogsteen or Watson-Crick conformations.

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