Summary information and primary citation
- PDB-id
- 4u9m; DSSR-derived features in text and JSON formats
- Class
- DNA
- Method
- X-ray (3.13 Å)
- Summary
- Structure of the DNA duplex d(attaat)2 with hoogsteen hydrogen bonds
- Reference
- Acosta-Reyes FJ, Alechaga E, Subirana JA, Campos JL (2015): "Structure of the DNA Duplex d(ATTAAT)2 with Hoogsteen Hydrogen Bonds." Plos One, 10, e0120241. doi: 10.1371/journal.pone.0120241.
- Abstract
- The traditional Watson-Crick base pairs in DNA may occasionally adopt a Hoogsteen conformation, with a different organization of hydrogen bonds. Previous crystal structures have shown that the Hoogsteen conformation is favored in alternating AT sequences of DNA. Here we present new data for a different sequence, d(ATTAAT)2, which is also found in the Hoogsteen conformation. Thus we demonstrate that other all-AT sequences of DNA with a different sequence may be found in the Hoogsteen conformation. We conclude that any all-AT sequence might acquire this conformation under appropriate conditions. We also compare the detailed features of DNA in either the Hoogsteen or Watson-Crick conformations.