Summary information and primary citation
- PDB-id
- 4u6k; DSSR-derived features in text and JSON formats
- Class
- DNA-RNA
- Method
- X-ray (1.5 Å)
- Summary
- Crystal structure of DNA-RNA duplex containing 2'-4'-bna-nc
- Reference
- Kondo J, Nomura Y, Kitahara Y, Obika S, Torigoe H (2016): "The crystal structure of a 2',4'-BNA(NC)[N-Me]-modified antisense gapmer in complex with the target RNA." Chem.Commun.(Camb.), 52, 2354-2357. doi: 10.1039/c5cc08300a.
- Abstract
- It has been confirmed by our previous studies that a 2',4'-BNA(NC)[N-Me]-modified antisense gapmer displays high affinity and selectivity to the target RNA strand, promising mRNA inhibitory activity and excellent nuclease resistance. Herein, we have obtained a crystal structure that provides insights into these excellent antisense properties.
