Summary information and primary citation

PDB-id
4elt; DSSR-derived features in text and JSON formats
Class
transferase-DNA
Method
X-ray (2.2 Å)
Summary
Snapshot of the large fragment of DNA polymerase i from thermus aquaticus processing modified pyrimidines
Reference
Obeid S, Busskamp H, Welte W, Diederichs K, Marx A (2012): "Interactions of non-polar and "Click-able" nucleotides in the confines of a DNA polymerase active site." Chem.Commun.(Camb.), 48, 8320-8322. doi: 10.1039/c2cc34181f.
Abstract
Modified nucleotides play a paramount role in many cutting-edge biomolecular techniques. The present structural study highlights the plasticity and flexibility of the active site of a DNA polymerase while incorporating non-polar "Click-able" nucleotide analogs and emphasizes new insights into rational design guidelines for modified nucleotides.

Cartoon-block schematics in six views (download the tarball)

PyMOL session file Download PDB file View in 3Dmol.js