DSSR-PyMOL cartoon-block schematics: PDB entry 3td0

PDB-id

3td0; DSSR-derived features in text and JSON formats

Class

RNA

Method

X-ray (1.6 Å)

Summary

Crystal structure of the bacterial a1408g-mutant and the protozoa cytoplasmic ribosomal decoding site

Reference

Kondo J (2012): "A structural basis for the antibiotic resistance conferred by an A1408G mutation in 16S rRNA and for the antiprotozoal activity of aminoglycosides." Angew.Chem.Int.Ed.Engl., 51, 465-468. doi: 10.1002/anie.201106084.

Abstract

Resistance explained: The crystal structures of the ribosomal decoding A site with an A1408G antibiotic-resistance mutation were solved in the presence and absence of the aminoglycoside geneticin (see structure, geneticin carbon framework in yellow). These structures show how bacteria acquire high-level resistance against aminoglycosides by the mutation.