DSSR-PyMOL cartoon-block schematics: PDB entry 3es0

PDB-id

3es0; DSSR-derived features in text and JSON formats

Class

DNA

Method

X-ray (2.2 Å)

Summary

A bimolecular anti-parallel-stranded oxytricha nova telomeric quadruplex in complex with a 3,6-disubstituted acridine bsu-6048

Reference

Campbell NH, Patel M, Tofa AB, Ghosh R, Parkinson GN, Neidle S (2009): "Selectivity in Ligand Recognition of G-Quadruplex Loops." Biochemistry, 48, 1675-1680. doi: 10.1021/bi802233v.

Abstract

A series of disubstituted acridine ligands have been cocrystallized with a bimolecular DNA G-quadruplex. The ligands have a range of cyclic amino end groups of varying size. The crystal structures show that the diagonal loop in this quadruplex results in a large cavity for these groups, in contrast to the steric constraints imposed by propeller loops in human telomeric quadruplexes. We conclude that the nature of the loop has a significant influence on ligand selectivity for particular quadruplex folds.