DSSR-PyMOL cartoon-block schematics: PDB entry 2km3

PDB-id

2km3; DSSR-derived features in text and JSON formats

Class

DNA

Method

NMR

Summary

Structure of an intramolecular g-quadruplex containing a g.c.g.c tetrad formed by human telomeric variant ctaggg repeats

Reference

Lim KW, Alberti P, Guedin A, Lacroix L, Riou JF, Royle NJ, Mergny JL, Phan AT (2009): "Sequence variant (CTAGGG)n in the human telomere favors a G-quadruplex structure containing a G.C.G.C tetrad." Nucleic Acids Res., 37, 6239-6248. doi: 10.1093/nar/gkp630.

Abstract

Short contiguous arrays of variant CTAGGG repeats in the human telomere are unstable in the male germline and somatic cells, suggesting formation of unusual structures by this repeat type. Here, we report on the structure of an intramolecular G-quadruplex formed by DNA sequences containing four human telomeric variant CTAGGG repeats in potassium solution. Our results reveal a new robust antiparallel G-quadruplex fold involving two G-tetrads sandwiched between a G.C base pair and a G.C.G.C tetrad, which could represent a new platform for drug design targeted to human telomeric DNA.