DSSR-PyMOL cartoon-block schematics: PDB entry 2g1w

PDB-id

2g1w; DSSR-derived features in text and JSON formats

Class

RNA

Method

NMR

Summary

NMR structure of the aquifex aeolicus tmrna pseudoknot pk1

Reference

Nonin-Lecomte S, Felden B, Dardel F (2006): "NMR structure of the Aquifex aeolicus tmRNA pseudoknot PK1: new insights into the recoding event of the ribosomal trans-translation." Nucleic Acids Res., 34, 1847-1853. doi: 10.1093/nar/gkl111.

Abstract

The transfer-messenger RNA (tmRNA) pseudoknot PK1 is essential for bacterial trans-translation, a ribosomal rescue mechanism. We report the solution structure of PK1 from Aquifex aeolicus, which despite an unprecedented small number of nucleotides and thus an unprecented compact size, displays a very high thermal stability. Several unusual structural features account for these properties and indicate that PK1 belongs to the class of ribosomal frameshift pseudoknots. This suggests a similarity between the mechanism of programmed ribosomal frameshifting and trans-translation.