Summary information and primary citation
- PDB-id
- 2bj6; DSSR-derived features in text and JSON formats
- Class
- nucleic acid (hna-RNA)
- Method
- X-ray (2.6 Å)
- Summary
- Crystal structure of a decameric hna-RNA hybrid
- Reference
- Maier T, Przylas I, Strater N, Herdewijn P, Saenger W (2005): "Reinforced Hna Backbone Hydration in the Crystal Structure of a Decameric Hna/RNA Hybrid." J.Am.Chem.Soc., 127, 2937. doi: 10.1021/JA045843V.
- Abstract
- The crystal structure of a decameric HNA/RNA (HNA = 2',3'-dideoxy-1',5'-anhydro-d-arabinohexitol nucleic acid) hybrid with the RNA sequence 5'-GGCAUUACGG-3' is the first crystal structure of a hybrid duplex between a naturally occurring nucleic acid and a strand, which is fully modified to contain a six-membered ring instead of ribose. The presence of four duplex helices in the asymmetric unit allows for a detailed discussion of hydration, which revealed a tighter spinelike backbone hydration for the HNA- than for the RNA-strands. The reinforced backbone hydration is suggested to contribute significantly to the exceptional stability of HNA-containing duplexes and might be one of the causes for the evolutionary preference for ribose-derived nucleic acids.
