Summary information and primary citation

1r3g; DSSR-derived features in text and JSON formats
X-ray (1.16 Å)
1.16a x-ray structure of the synthetic DNA fragment with the incorporated 2'-o-[(2-guanidinium)ethyl]-5-methyluridine residues
Prakash TP, Lesnik E, Mohan V, Tereshko V, Egli M, Manoharan M (2004): "2'-O-[2-(Guanidinium)ethyl]-Modified Oligonucleotides: Stabilizing Effect on Duplex and Triplex Structures." Org.Lett., 6, 1971-1974. doi: 10.1021/ol0493249.
[structure: see text] Oligonucleotides with a novel 2'-O-[2-(guanidinium)ethyl] (2'-O-GE) modification have been synthesized using a novel protecting group strategy for the guanidinium group. This modification enhances the binding affinity of oligonucleotides to RNA as well as duplex DNA (DeltaT(m) 3.2 degrees C per modification). The 2'-O-GE modified oligonucleotides exhibited exceptional resistance to nuclease degradation. The crystal structure of a palindromic duplex formed by a DNA oligonucleotide with a single 2'-O-GE modification was solved at 1.16 A resolution.

Cartoon-block schematics in six views (download the tarball)

PyMOL session file Download PDB file View in 3Dmol.js