Summary information and primary citation

1nfk; DSSR-derived features in text and JSON formats
X-ray (2.3 Å)
Structure of the nuclear factor kappa-b (nf-kb) p50 homodimer
Ghosh G, van Duyne G, Ghosh S, Sigler PB (1995): "Structure of NF-kappa B p50 homodimer bound to a kappa B site." Nature, 373, 303-310. doi: 10.1038/373303a0.
The 2.3-A crystal structure of the transcription factor NK-kappa B p50 homodimer bound to a palindromic kappa B site reveals that the Rel homology region folds into two distinct domains, similar to those in the immunoglobulin superfamily. The p50 dimer envelopes an undistorted B-DNA helix, making specific contacts along the 10-base-pair kappa B recognition site mainly through loops connecting secondary structure elements in both domains. The carboxy-terminal domains form a dimerization interface between beta-sheets using residues that are strongly conserved in the Rel family.

Cartoon-block schematics in six views (download the tarball)

PyMOL session file Download PDB file View in 3Dmol.js