DSSR-PyMOL cartoon-block schematics: PDB entry 176d

PDB-id

176d; DSSR-derived features in text and JSON formats

Class

peptide nucleic acid-RNA

Method

NMR

Summary

NMR solution structure of a peptide nucleic acid complexed with RNA

Reference

Brown SC, Thomson SA, Veal JM, Davis DG (1994): "NMR solution structure of a peptide nucleic acid complexed with RNA." Science, 265, 777-780.

Abstract

Peptide nucleic acids (PNA) incorporating nucleic acid bases into an achiral polyamide backbone bind to DNA in a sequence-dependent manner. The structure of a PNA-ribonucleic acid (RNA) complex was determined with nuclear magnetic resonance methods. A hexameric PNA formed a 1:1 complex with a complementary RNA that is an antiparallel, right-handed double helix with Watson-Crick base pairing similar to the "A" form structure of RNA duplexes. The achiral PNA backbone assumed a distinct conformation upon binding that differed from previously proposed models and provides a basis for further structure-based design of antisense agents.