Summary information and primary citation
- PDB-id
-
103d;
SNAP-derived features in text and
JSON formats
- Class
- DNA
- Method
- NMR
- Summary
- The unusual structure of the human centromere (gga)2
motif: unpaired guanosine residues stacked between sheared
g(dot)a pairs
- Reference
-
Chou SH, Zhu L, Reid BR (1994): "The unusual
structure of the human centromere (GGA)2 motif. Unpaired
guanosine residues stacked between sheared G.A
pairs." J.Mol.Biol., 244,
259-268. doi: 10.1006/jmbi.1994.1727.
- Abstract
- The centromere of human chromosomes contains multiple
repeats of the DNA sequence d(TGGAA)n. This sequence has
the interesting property of pairing with itself to form
stable duplexes. We have determined the solution structure
of the unusual DNA duplex 5'-TGGAATGGAA:TGGAATGGAA-3' at
atomic resolution. The duplex contains unpaired staggered
guanosine residues, which co-stack by intercalation between
sheared G.A and A.G base-pairs to form an interesting new
structural motif, the GA-bracketed G-stack. The TGGAA
repeat unit contains six "steps", four of which are not
Watson-Crick base-pairs.
